Green Bay is the -249 money line favorite (risk $249 to win $100), while San Francisco is the +202 underdog. Before locking in any Packers vs. 49ers picks, you'll want to see the NFL predictions and betting advice from the proven computer simulation model ...

SanFran is in a three-way tie for second in the NFC West, one game behind the first-place Arizona Cardinals. The Packers are 38-34-1 against the 49ers, though San Francisco has won the last two meetings, both coming in the playoffs.

Brock Purdy was a late-week scratch for Sunday’s game between the San Francisco 49ers and Green Bay Packers due to a bad shoulder, moving the spread for that game a full four points from Packers -1.5 to -5.