Sox9, a master regulator of cartilage formation, switches its target genes dynamically during embryonic limb development instead of following a fixed program, as reported by researchers from Science ...

Researchers have shown how gene mutations may cause common forms of cartilage tumors. In a new study, they have revealed that mutations in the isocitrate dehydrogenase (IDH) gene contribute to the ...

Researchers have identified modes of Sox9 action during cartilage formation by analyzing big data on Sox9 location, chromatin state, and gene expression over the whole mouse genome. This finding will ...

Cartilage is largely composed of a single type of cells, called chondrocytes and various types of extracellular matrix proteins including highly sulfated macromolecule proteoglycans, small ...

A recent article in Engineering describes the development of a protein-based nanocomposite hydrogel designed to deliver two therapeutic agents—dexamethasone (Dex) and kartogenin (KGN)—to support ...

DURHAM, N.C. - Duke Medicine researchers have shown how gene mutations may cause common forms of cartilage tumors. In a study published in the Feb. 16, 2015, issue of the Proceedings of the National ...