The research team developed a genetically engineered mouse model carrying a mutation (E3896A) in RyR1, which disrupts its calcium-binding site, effectively disabling CICR while preserving ...

The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...

The flow of water within a muscle fiber may dictate how quickly muscle can contract, according to a new study. The flow of water within a muscle fiber may dictate how quickly muscle can contract, ...

The contraction of smooth muscle is an essential process underpinning diverse physiological functions ranging from gastrointestinal motility to vascular regulation. At its core, smooth muscle ...

Myotonic dystrophy type 1 (DM1) is the most common form of adult-onset muscular dystrophy, affecting about 1 in 8,000 people.