Integrins are heterodimeric transmembrane receptors that mediate adhesion to the extracellular matrix and engage bidirectional signalling across the plasma membrane. Activation is controlled by ...
Integrins are heterodimeric transmembrane receptors that mediate adhesion between cells and the extracellular matrix, orchestrating bidirectional signalling that governs cancer cell behaviour. In the ...
A research team led by Junior Associate Professor Masato Nakagawa (Department of Life Science Frontiers) investigated the effects of basic fibroblast growth factor (bFGF) and its interactions with ...
(A) CD47 associates with SIRPĪ± on immune cells via its N-terminal domain, triggering the phosphorylation of the ITIMs and subsequent recruitment of SHP1/2, thereby inhibiting phagocytosis. (B) TSP1 ...
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