Iron--sulfur (Fe--S) proteins, essential to all life forms, are difficult to synthesise due to the complicated molecular machinery involved and sensitivity of Fe--S clusters to oxygen. In a new study, ...

Iron is essential to virtually all living organisms but can be toxic when present in excess. In the cell, iron is mainly found in metalloproteins in one of three forms: as mono-/di-nuclear ions, in ...

The activity of ATE1, which flags misfolded proteins for destruction, is enhanced by binding iron-sulfur clusters. It's also highly sensitive to oxygen, which may indicate it moderates the cell's ...

Research on Atm1 protein’s role in iron-sulfur cluster transport across membranes could improve our understanding of mitochondrial conditions. A ubiquitous protein family found in almost all ...

Friedreich's ataxia (FA) is a rare but devastating genetic disorder. Those with the condition are often diagnosed between 5 and 15 years of age and live only into their 30s or 40s. There is no widely ...

Sulfur compounds play a crucial role in animal physiology, particularly in the context of inflammation. These compounds, absorbed as sulfur amino acids like methionine and cysteine, are vital for ...

Fe–S clusters, which are a part of Fe–S proteins, are found across all forms of life. They play a significant role as biological cofactors—helper molecules that assist these proteins in different ...