Missing DNA replication step revealed in first image of pre-initiation complex

Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment ...
Nature

Retraction Note: Cyclin-dependent kinase 4/6 activity is a critical determinant of pre-replication complex assembly

The Editors-in-Chief have retracted this article. Concerns were raised regarding figure 5, specifically that blots have been reused between papers in different experimental contexts [1]. The authors ...
Phys.org

Researchers reveal how DNA unzipping machine MCM2-7 complex works, with implications for cancer therapy

A research team led by Dr. Yuanliang Zhai from the School of Biological Sciences, The University of Hong Kong (HKU), and his collaborators from The Hong Kong University of Science and Technology ...
EurekAlert!

HKU biologists and collaborators reveal how DNA unzipping machine works, shedding lights on cancer therapy

A research team led by Dr Yuanliang ZHAI from the School of Biological Sciences, The University of Hong Kong (HKU), and his collaborators from The Hong Kong University of Science and Technology (HKUST ...
Nature

Distinct roles of Arabidopsis ORC1 proteins in DNA replication and heterochromatic H3K27me1 deposition

The cell cycle is a highly regulated and conserved cellular process aiming at producing two daughter cells. After cell division, the G1 period is characterized by different events including a ...