Scientists are uncovering how sirtuins connect energy metabolism, mitochondrial resilience, and stress-response pathways to ...

Scientists from Johns Hopkins and the University of Wisconsin have discovered that a protein called Sir2, which is found in nearly all living cells, has a new function that might help explain how ...

Keeping mitochondria healthy may be the secret to a long life, according to new work on the sirtuins, a family of enzymes that regulate aging and lifespan. The research shows that cells under stress ...

The enzyme sirtuin 6, or SIRT6, serves many key biological functions in regulating genome stability, DNA repair, metabolism and longevity, but how its multiple enzyme activities relate to its various ...