Zinc finger nucleases (ZFNs) have great potential for translational research and clinical use. Scientists succeeded in the efficient construction of functional ZFNs and the improvement of their genome ...

Resulting animals had permanent heritable mutations, according to paper in Science. A group of scientists report the creation of the first genetically modified rats using Sangamo Biosciences zinc ...

Zinc finger nucleases are designed to be like heat-seeking missiles, precisely targeted to find and cut specific sequences of DNA. Occasionally, however, they may snip the wrong spot, causing ...

Genome editing is a powerful biotechnology tool that allows scientists to make precise changes to an organism's DNA. It involves the use of specialized enzymes, known as engineered nucleases or ...

Dana Carroll must be considered one of the deans of genome editing. He was instrumental in the development of zinc finger nucleases (ZFNs), the genome editing tool that predates CRISPR-Cas by a full ...