In a statement shared with PEOPLE, Wyle, 54, said of the nominations, including one for outstanding lead actor in a drama series, "I’m humbled and grateful"

Seth Rogen, Stephen Graham, Noah Wyle, Katherina LaNasa and more reacted to their Emmy nominations, which were announced Tuesday morning.

Wyle's nod marks his first Emmy nomination in 26 years and his first ever in the category. But the actor is certainly no stranger to grabbing the attention of Emmy voters; this is his sixth Emmy nomination — and his sixth time turning voters' heads while wearing scrubs.