eLife2d
Human DCP1 is crucial for mRNA decapping and possesses paralog-specific gene regulating functions
For mRNA decapping by enhancing DCP2's mRNA-binding affinity and regulating distinct biological processes through DCP1a and DCP1b, human DCP1 is essential.
eLife2d
Stochastic cell-intrinsic stem cell decisions control colony growth in planarians
The School of Neurobiology, Biochemistry & Biophysics, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel ...
eLife2d
Distinct functions of three Wnt proteins control mirror-symmetric organogenesis in the C. elegans gonad
Organogenesis requires the proper production of diverse cell types and their positioning/migration. However, the coordination of these processes during development remains poorly understood. The gonad ...
eLife3d
RNase III in Salmonella Enteritidis enhances bacterial virulence by reducing host immune responses
This useful study examines the function of the rnc gene, which encodes the RNase III ribonuclease, as it relates to virulence of Salmonella Enteritidis. The authors demonstrate that the rnc gene is ...
eLife3d
Exceptional longevity of mammalian ovarian and oocyte macromolecules throughout the reproductive lifespan
Exceptionally long-lived macromolecules in mammalian ovaries and oocytes serve as pillars for lifelong reproductive health span.
eLife4d
Protein absorption in the zebrafish gut is regulated by interactions between lysosome rich enterocytes and the microbiome
Dietary protein absorption in neonatal mammals and fishes relies on the function of a specialized and conserved population of highly absorptive lysosome rich enterocytes (LREs). The gut microbiome has ...
eLife4d
HIV-1 Vif disrupts phosphatase feedback regulation at the kinetochore, leading to a pronounced pseudo-metaphase arrest
This valuable study uses robust time-dependent microscopy assays to show that during HIV-1 infection, the viral accessory protein Vif causes cell cycle arrest during metaphase and not G2/M as ...
eLife3d
Proteostasis modulates gene dosage evolution in antibiotic-resistant bacteria
This important study explores the interplay between gene dosage and gene mutations in the evolution of antibiotic resistance. The authors provide solid evidence to connect proteostasis with gene ...
eLife4d
Notch Signaling: Antibodies get under the skin
By inhibiting receptor-ligand interactions in sebaceous glands, antibodies may be able to treat certain skin conditions.
eLife6d
Immune Cells: Growing microglia in the lab
Transplanting microglia derived from human stem cells into mice reveals new possibilities for treating neurodegenerative eye diseases.
eLife9d
Being Neurodivergent in Academia: Navigating neurodiversity in higher education in India
True inclusion starts in academia when we move from a deficit-based perspective to one that recognises and nurtures the unique strengths and talents of neurodivergent individuals.
eLife4d
Spatial transcriptomics of meningeal inflammation reveals inflammatory gene signatures in adjacent brain parenchyma
Leptomeningeal inflammation in a mouse model of multiple sclerosis triggers deeply penetrating gene changes in underlying brain tissue, described using spatial transcriptomics.