Introduction Tezepelumab, a human monoclonal antibody targeting TSLP, inhibits T2 inflammation leading to a fall in both the blood eosinophil count (Eos) and fractional exhaled nitric oxide (FeNO) ...
Background Asthma remains the most common chronic disease in children and the UK has some of the poorest asthma outcomes in Europe. The socio demographic inequalities contribute to severe asthma ...
Background Bronchoalveolar lavage (BAL) is essential in determining the efficacy of novel therapies in alpha-1 antitrypsin deficiency (AATD). These require initial proof-of-concept demonstration that ...
Background The evidence base on montelukast-associated adverse outcomes is inconclusive in children and young persons (CYP) with asthma. We aimed to investigate 1-year incidence of neuropsychiatric ...
2 Institute of Respiratory Medicine, University of Sydney, NSW, Australia 3 South Western Sydney Clinical School, University of New South Wales, NSW, Australia Background: Sahaja Yoga is a traditional ...
Background Patient perception of asthma treatment is rarely captured, and no specific tools exist to measure it. We developed an inhouse severe asthma patient feedback questionnaire (SAPFQ) using ...
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Introduction and Objectives Gene therapy for cystic fibrosis is approaching clinical trials. Using a lentiviral vector pseudotyped with Sendai virus fusion and hemagglutinin-neuraminidase proteins, ...
Atypical radiological manifestation of sarcoidosis presenting with an anterior mediastinal mass ...
Rationale Endoscopic lung volume reduction improves lung function, quality of life and exercise capacity in severe emphysema patients. However, its effect on the diaphragm function is not well ...
Dr L G Heaney, Department of Respiratory Medicine, Level 8, Belfast City Hospital, Lisburn Road, Belfast, Northern Ireland BT9 7AB. BACKGROUND Multiple sensory neuropeptides are present in human ...
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