KEY POINTS A 22-year-old White man presented to the emergency department with a 2-month history of progressive fatigue, intermittent abdominal pain, constipation, and dyspnea. He had gained 27 kg over ...

In Canada, an estimated 5400 deaths attributable to AMR occurred in 2018.[1][1] By 2050, 40% of infections will be resistant to first-line antimicrobials.[1][1] The pan-Canadian action plan on AMR has ...

See related research at KEY POINTS In this issue of CMAJ , Van and colleagues present a cost–utility analysis of several different strategies for introduction of guideline-directed medical therapy ...

Background: Standard pharmacotherapy for patients with heart failure with reduced ejection fraction (HFrEF) comprises “quadruple therapy” with a renin–angiotensin system inhibitor, a β-blocker, a ...

Anal cancer is caused mainly by human papillomavirus (HPV), most commonly HPV-16. It occurs in 1–2 per 100 000 people in the general population, increases with older age, and is rare in those younger ...

KEY POINTS A 35-year-old woman was admitted to a community hospital for sepsis caused by Streptococcus pyogenes bacteremia, ...

Correction to “Advances in the management of renal cell carcinoma” ...

Early pregnancy loss, also known as miscarriage, is common, distressing, and frequently poorly managed in Canada. Diagnosis of early pregnancy loss requires determination of serum β-human chorionic ...