With only a few weeks left on the college football slate, NFL draft season is beginning to hit its stride. Before the San Francisco 49ers meet the Buffalo Bills in Week 13, USA TODAY’s NFL Draft Wire released their latest predictions for the 2025 draft with a new mock draft.

Before you make any Week 13 NFL picks, be sure to see the exact NFL score predictions from SportsLine expert Eric Cohen. Cohen, a SportsLine NFL expert and host of the Friday "Early Edge NFL Props Show" on SportsLine's YouTube page,

The 49ers have dealt with injuries to key players all season. Brandon Aiyuk injured his knee, Brock Purdy missed last week's game, and Fred Warner has a lingering ankle issue.

San Francisco 49ers star linebacker Fred Warner revealed Wednesday that he has been playing through a broken bone in his ankle since September.

Who plays whom in NFL Week 13? Take a look at the 16 games on the Week 13 NFL schedule this week, starting with three games on Thanksgiving (Chicago Bears vs Detroit Lions, New York Giants vs Dallas Cowboys,

NFL Week 13 odds, picks, predictions, TV and streaming information for Sunday Night Football game between the San Francisco 49ers and Buffalo Bills.

The Buffalo Bills might have a chance to clinch the AFC East on Sunday night when they battle the injury-decimated San Francisco 49ers at Orchard Park, N.Y. Buffalo (9-2) has

It’s Week 13 in the NFL, and the Buffalo Bills are preparing to host the San Francisco 49ers on Sunday Night Football at 8:20 p.m. Buffalo (9-2) enters the contest having won six straight and is coming off a bye week. Meanwhile, San Francisco (5-6) has dropped two straight and three of five as injuries continue to pile up.

Bills' QB Josh Allen is the current favorite for MVP. Expectations aren't something I like to make a habit. However, it's hard not to expect the best from Allen and the Bills this week. Beating the Chiefs the way they did helped them check off that confidence box, and they did it on their 12th straight week of football.

Christian McCaffrey and the 49ers travel to Buffalo to take on Josh Allen and the Bills for Sunday Night Football. Live coverage begins at 7 PM ET on NBC and Peacock.