Zinc finger nucleases (ZFNs) have great potential for translational research and clinical use. Scientists succeeded in the efficient construction of functional ZFNs and the improvement of their genome ...

Resulting animals had permanent heritable mutations, according to paper in Science. A group of scientists report the creation of the first genetically modified rats using Sangamo Biosciences zinc ...

Sigma Life Science, the innovative biological products and services research business of Sigma-Aldrich (SIAL), announced the release of its pre-designed CompoZr Knockout Zinc Finger Nucleases (ZFNs) ...

From top, ZFNs on both sides of the DNA strand target a site upstream of the gene where most hemophilia-causing mutations reside. The ZFNs then cut both strands of the DNA double helix. As homologous ...

Dana Carroll must be considered one of the deans of genome editing. He was instrumental in the development of zinc finger nucleases (ZFNs), the genome editing tool that predates CRISPR-Cas by a full ...

Zinc finger nucleases are designed to be like heat-seeking missiles, precisely targeted to find and cut specific sequences of DNA. Occasionally, however, they may snip the wrong spot, causing ...