In a season where running backs are thriving in the NFL, the 49ers hope to get Christian McCaffrey back on track.

Speaking with reporters on Wednesday, San Francisco 49ers head coach Kyle Shanahan says it's "unfair" to expect running back ...

San Francisco 49ers running back Christian McCaffrey is three games into his return from injury. The two-time first-team ...

The San Francisco 49ers are reeling and now head to Buffalo for a prime time game. Will they have their starting QB back in ...

With criticism mounting, San Francisco 49ers head coach Kyle Shanahan responded to inquiries about his individual job ...

After fielding one of the best-rushing offenses in the NFL, with Jordan Mason leading the way and Isaac Guerendo rounding out ...

The 49ers happened to have room at quarterback amid Brock Purdy's injury. Kyle Shanahan revealed if Daniel Jones was a ...

Amid a wicked Super Bowl hangover and heading towards what is likely a losing season, it’s natural that head coach Kyle ...

SANTA CLARA — While Brock Purdy resumed practicing through a shoulder issue and Dre Greenlaw made a much-anticipated debut ...

Christian McCaffrey has been inefficient in his three games played since dealing with Achilles tendinitis. He doesn't look ...

Bad news for the 49ers. Brock Purdy still isn't ready to resume throwing. Technically, he threw one pass on Wednesday -- a ...

The 49ers are struggling at 5-6. They have a tough game in Buffalo on Sunday night. A loss would further complicate their ...