49ers head coach Kyle Shanahan told reporters Monday that McCaffrey suffered a posterior cruciate ligament (PCL) injury ...

Trevor Lawrence, Christian McCaffrey and Taysom Hill were among key players injured in Week 13 of the NFL season.

San Francisco 49ers running back Christian McCaffrey left Sunday night's contest versus the Buffalo Bills with what the team ...

The 49ers star running back was ruled out of Sunday Night Football after suffering a knee injury in the first half against ...

Ever since making the switch from high school receiver to running back in college, Isaac Guerendo has had few opportunities ...

Having suffered a knee injury that landed him on injured reserve during a snowy loss to the Bills on Sunday night, 49ers ...

Running back Christian McCaffrey is on injured reserve for the second time this season, but San Francisco 49ers coach Kyle ...

Christian McCaffrey's injury-ridden season took another unfortunate turn when the star running back went down with another ...

McCaffrey should be fine long term, though it's hard to say whether he'd be able to play again this season if the 49ers made ...

San Francisco 49ers running back Christian McCaffrey scared NFL fans across the country this Wednesday with a heartfelt ...

Christian McCaffrey on Wednesday shared his first message to his fans after suffering a season-ending injury on Sunday.

Christian McCaffrey suffered a torn PCL in the San Francisco 49ers' 35-10 Week 13 loss to the Buffalo Bills. The injury is ...