AbstractPurpose:. Patients with melanoma progressing on immune checkpoint blockade may benefit from adoptive transfer of tumor-infiltrating lymphocytes (TIL).Patients and Methods:. We investigated the ...

In 1775, English surgeon Percivall Pott discovered that exposure to soot in chimneys caused scrotal cancer in chimney sweeps, the first time an agent found in the workplace was directly connected to ...

AbstractPurpose:. Pelareorep (Pel) is a type 3 oncolytic reovirus that upregulates PD-L1 expression. We determined the objective response rate (ORR) with paclitaxel (Pac), Pac + Pel, or Pac + Pel + ...

Abstract. The integration of artificial intelligence (AI) in cancer research has significantly advanced radiology, pathology, and multimodal approaches, offering unprecedented capabilities in image ...

Abstract. Radiomics, the extraction of quantitative data from images, holds promise for noninvasively characterizing tumor phenotypes. Tools like LIFEx have improved the accessibility, transparency, ...

Homologous recombination is a high-fidelity DNA repair mechanism essential for maintaining genome stability. Impairment of this pathway, often due to BRCA1 or BRCA2 inactivation, leads to homologous ...

AbstractPurpose:. The VISION trial of tepotinib, a selective MET inhibitor, enrolled patients with non–small cell lung cancer and prospectively detected MET exon 14 (METex14) skipping in liquid ...

A new AI platform turns a general-purpose language model into an autonomous clinical agent that can analyze diagnostic data, interpret imaging and pathology, and generate treatment plans for patients ...

CAR T-cell therapy can successfully treat chemotherapy-resistant B-cell malignancies but has limited effectiveness against solid tumors. The authors report that a fully human CAR targeting the STn ...

An Iranian missile hit the campus of Israel’s Weizmann Institute of Science, destroying many cancer research labs. Researchers mourned the loss of expensive equipment and irreplaceable samples and ...

A federal judge ruled today that recent layoffs at certain Department of Health and Human Services (DHHS) divisions were likely unlawful and blocked the Trump administration from finalizing these ...

The FDA today granted accelerated approval to linvoseltamab (Lynozyfic, Regeneron) for adults with relapsed or refractory multiple myeloma who have already received at least four therapeutic regimens.