For the first time, a molecular mechanism is identified, for experimental acceleration and deceleration (rejuvenation) of sperm epigenetic aging.

Structural studies reveal the mechanism by which the mRNA nuclear export machinery engages with nascent transcripts through interaction with the cap binding complex.

Wong et al. (2019) used a sensory preconditioning protocol to examine how sensory and fear memories are integrated in the rat medial temporal lobe. In this protocol, rats integrate a sound-light ...

Pathogenic activating point mutations in the LRRK2 kinase cause autosomal-dominant familial Parkinsońs disease (PD). In cultured cells, mutant LRRK2 causes a deficit in de novo cilia formation and ...

In this study, we investigated the neuronal activity of the dentate gyrus (DG) with electrophysiological and optical imaging tools during sleep-wake cycles. We found that the activity of major ...

In the DDM, noisy evidence is accumulated into a decision variable until reaching one of the two bounds, representing commitment to one of two choices (e.g., left or right). In general, the average ...

The accumulation of SIRT4 in the nuclei of kidney cells drives kidney fibrosis, so blocking the movement of this protein could be a potential therapeutic strategy against fibrosis.

Nearly a thousand diverse adaptive mutants converge into a handful of groups for which fitness responds the same way to ...

CUTS is a cryptic exon RNA biosensor enabling real-time detection of TDP-43 loss of splicing function. CUTS exhibits a significant linear relationship with TDP-43 loss. CUTS can deliver an ...

Interdepartmental Graduate Program in Dynamical Neuroscience, University of California, Santa Barbara Although grid cells are one of the most well studied functional classes of neurons in the ...

The authors present a valuable study exploring the interaction between JNK signaling and high sucrose feeding. The strength of evidence supporting these observations is solid, including multi-tissue ...

One year after forming this Committee, we’re inviting applications from researchers in the Global South to join for a term ...