San Francisco 49ers running back Christian McCaffrey was placed on injured reserve for the second time this season after ...

Ever since making the switch from high school receiver to running back in college, Isaac Guerendo has had few opportunities ...

Christian McCaffrey's injury-ridden season took another unfortunate turn when the star running back went down with another ...

Running back Christian McCaffrey is on injured reserve for the second time this season, but San Francisco 49ers coach Kyle ...

The 28-year-old took to social media on Wednesday to share a heartfelt message for 49ers fans after his injury-plagued ...

ET on Sunday, the Chicago Bears play at the San Francisco 49ers.In their last outing, the 49ers lost 35-10 to the Buffalo ...

The San Francisco 49ers on Wednesday continued adjusting to life without running backs Christian McCaffrey and Jordan Mason.

McCaffrey should be fine long term, though it's hard to say whether he'd be able to play again this season if the 49ers made ...

A spate of injuries has derailed the 49ers' Super Bowl hopes his season, but the bigger question is if their title window has ...

The Buffalo Bills stuck it to “the man” after their win over the San Francisco 49ers. The Bills (10-2) won in Week 13 over ...

Following their win over the San Francisco 49ers, the Bills (10-2) will take on the Los Angeles Rams (6-6) at SoFi Stadium in ...

When Kyle Shanahan became head coach of the San Francisco 49ers in 2017, the team was in the midst of a rebuilding phase.