San Francisco is in desperation mode after back-to-back losses and find itself as a touchdown underdog in Buffalo.

The Buffalo Bills have shared a clip of intense snow covering Highmark Stadium ahead of their game with the San Francisco ...

Snow has blanketed Orchard Park, New York, where the Buffalo Bills will play the San Francisco 49ers on Sunday Night Football ...

Four NFL games on Thanksgiving and Black Friday kicked off Week 13 action, and the full schedule continues on Sunday, Dec. 1, ...

One of the best receivers in the league will be on display when George Kittle and the San Francisco 49ers visit the Buffalo ...

Coming into the 2024 NFL season, it wouldn't have been out of the ordinary to find a Super Bowl prediction featuring the ...

The San Francisco 49ers saw their playoff chances plummet following consecutive losses to the Seattle Seahawks and Green Bay ...

Buffalo Bills linebacker Matt Milano (58) reacts after a defensive play against the New York Jets during the first quarter of ...

The San Francisco 49ers (5-6) try to salvage their season against the Buffalo Bills (9-2) on Sunday Night Football. Kickoff ...

Ten months after their wild-card playoff game against the Pittsburgh Steelers was postponed due to blizzard conditions, the ...

The #Bills have activated Pro Bowl LB Matt Milano off Injured Reserve and he’ll play on Sunday against the #49ers for the ...

The Buffalo Bills have activated Matt Milano from injured reserve, putting the starting linebacker in position to play Sunday ...