San Francisco is in desperation mode after back-to-back losses and find itself as a touchdown underdog in Buffalo.

The Bills return from the bye for a primetime showdown with the 49ers in NFL Week 13 on Sunday, Dec. 1 at Highmark Stadium.

The San Francisco 49ers will take on the Buffalo Bills in the Week 13 edition of NBC's "Sunday Night Football." What to know ...

The Buffalo Bills have shared a clip of intense snow covering Highmark Stadium ahead of their game with the San Francisco ...

Snow has blanketed Orchard Park, New York, where the Buffalo Bills will play the San Francisco 49ers on Sunday Night Football ...

One of the best receivers in the league will be on display when George Kittle and the San Francisco 49ers visit the Buffalo ...

The Buffalo Bills (9-2) take a six-game winning streak into their contest with the San Francisco 49ers on Sunday, December 1, ...

Buffalo Bills linebacker Matt Milano (58) reacts after a defensive play against the New York Jets during the first quarter of ...

The San Francisco 49ers (5-6) try to salvage their season against the Buffalo Bills (9-2) on Sunday Night Football. Kickoff ...

Ten months after their wild-card playoff game against the Pittsburgh Steelers was postponed due to blizzard conditions, the ...

You can listen on SiriusXM satellite radio on channel 225 (Bills feed) and channel 226 (49ers feed), and on traditional radio ...

NFL Week 13 odds, picks, predictions, TV and streaming information for Sunday Night Football game between the San Francisco ...