The Bills are 9-2, their best start since 1992, and with a win would clinch their fifth straight AFC East title.

Tight end Kincaid will miss a second consecutive game when the Bills host the Niners at Highmark Stadium on Sunday.

The Bills return from the bye for a primetime showdown with the 49ers in NFL Week 13 on Sunday, Dec. 1 at Highmark Stadium.

Neil Reynolds, Jeff Reinebold and Phoebe Schecter discuss San Franciscos playoff prospects on the Inside The Huddle Pofcast; ...

As the 49ers prepare for their Week 13 matchup against the Bills, Brock Purdy will be the signal caller after being listed as ...

On Saturday night, ESPN's Adam Schefter reported that San Francisco 49ers quarterback Brock Purdy, officially listed as ...

While making updates to the team’s injury report, the San Francisco 49ers announced that left tackle Trent Williams will miss ...

When Brock Purdy started looking visibly uncomfortable during the fourth quarter of his Week 11 showdown against the Seattle ...

According to ESPN's Adam Schefter, San Francisco 49ers quarterback Brock Purdy (shoulder) is anticipated to play in Sunday ...

The Buffalo Bills are set to host another dangerous winter storm this Sunday with 2 to 3 feet of snow forecast ahead of ...

It looks like the San Francisco 49ers might get their quarterback back under center in time for a Week 13 matchup with the ...

The results were ugly for the San Francisco 49ers last week against the Green Bay Packers without starting quarterback Brock ...