Background Severe asthma is a chronic lung disease characterised by inflammation, airway hyperresponsiveness (AHR) and airway remodelling. The molecular mechanisms underlying uncontrolled airway ...
Background Reduced forced expiratory volume (FEV 1) and forced vital capacity (FVC) are risk factors for myocardial infarction (MI) and stroke. However, the relationship with incidence of heart ...
Background Community acquired pneumonia (CAP) is a leading cause of hospitalisation in older adults and is associated with greater likelihood of adverse outcomes. Given the ageing population and lack ...
Primary ciliary dyskinesia (PCD) is a rare autosomal recessive disorder in which the motile cilia are usually static or dyskinetic. The movement of mucus along the mucociliary escalator is impeded by ...
Introduction Chronic rhinosinusitis with nasal polyposis (CRSwNP) affects a significant proportion of people with severe asthma (SA). Despite the effectiveness of anti-IL5/5R therapies in the ...
Background and Aims The SARS-CoV-2 (COVID-19) pandemic caused significant global mortality and morbidity. Recent studies report residual lung abnormalities (RLA) and evidence of lung fibrosis in some ...
Introduction Tezepelumab, a human monoclonal antibody targeting TSLP, inhibits T2 inflammation leading to a fall in both the blood eosinophil count (Eos) and fractional exhaled nitric oxide (FeNO) ...
Introduction With improving cancer outcomes, indeterminate pulmonary lesions following radically-treated cancer are increasingly common, posing a diagnostic challenge of underlying aetiology. Existing ...
12 Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada Correspondence to Dr Wan C Tan, UBC James Hogg Research Centre, Providence Heart+Lung Institute, University of ...
Environmental factors, here taken to include pollutants, lifestyle factors and behaviours, can play an important role in serious, chronic pathologies with large societal and economic costs, including ...
Background Asthma remains the most common chronic disease in children and the UK has some of the poorest asthma outcomes in Europe. The socio demographic inequalities contribute to severe asthma ...
8 Biometrics, Late-stage Development, Respiratory and Immunology, BioPharmaceuticals RandD, AstraZeneca, Cambridge, UK 9 Late-stage Development, Respiratory and ...
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