Pregame analysis and predictions of the San Francisco 49ers vs. Los Angeles Rams NFL game to be played on September 22, 2024 on ESPN.

The San Francisco 49ers will be without receiver Deebo Samuel and running back Christian McCaffrey when they take on the Los Angeles Rams in Week 3, but two more key starters missed practice on Thursday due to injury: Tight end George Kittle and cornerback Charvarius Ward.

The San Francisco 49ers will get a key component of their defense back from injury as they face the Los Angeles Rams this weekend.

A senior Russian lawmaker on Thursday said that Ukrainian strikes on Russia with Western missiles would lead to global war with the use of nuclear weapons and that Moscow's response would be tough with more powerful weapons.

A close ally of President Vladimir Putin warned Western governments on Thursday that a nuclear war would ensue if they gave the green light for Ukraine to use long-range Western weapons to strike targets deep inside Russia.

Ukraine said it destroyed a large weapons stockpile in Russia overnight using long-range drones to stage the attack as Kyiv awaits US permission to use western-made missiles in such operations.