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Daily CRISPR Updates on Instagram: "Integrating large DNA segments – more than one kilobase – efficiently using CRISPR-Cas9 tools is challenging. The RED-CRISPR method, which combines recombinases (Redα/β) with CRISPR-Cas9, now offers a powerful approach for precise kilobase-scale DNA insertion. This tool makes homology-directed repair – a natural way cells fix DNA by using a matching DNA template to insert new DNA accurately – 2 to 5 times more efficient. Up to 45% knock-in efficiency was achie
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