AHA 2022: Bivalirudin With a Post-PCI High-Dose Infusion versus Heparin Monotherapy During Primary PCI in STEMI - The Randomized BRIGHT-4 Trial
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Replying to @DHAYOS Classes of Anticoagulants \t1.\tVitamin K Antagonists (VKAs) \t•\tExample: Warfarin \t•\tMechanism: Inhibits vitamin K–dependent clotting factors (II, VII, IX, X) \t2.\tHeparins \t•\tUnfractionated Heparin (UFH) – IV injection \t•\tLow Molecular Weight Heparin (LMWH) – e.g., Enoxaparin, Dalteparin \t•\tMechanism: Enhances antithrombin III, inhibiting thrombin and Factor Xa \t3.\tDirect Oral Anticoagulants (DOACs) / Non-VKA Oral Anticoagulants (NOACs) \t•\tFactor Xa inhibitors
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@mcq_medclub on Instagram: "Correct Answer is Stop heparin and give argatroban 🩸 Explanation: 👉 This patient has Heparin-Induced Thrombocytopenia (HIT). Key features of HIT: ↓ Platelets (thrombocytopenia) ⚠️ Paradoxical thrombosis (clots) Occurs 5–10 days after starting heparin Immune-mediated (IgG against heparin–PF4 complex) So, management is: ➡️ Immediately stop all heparin ➡️ Start a non-heparin anticoagulant → Argatroban / Bivalirudin ❌ Stop heparin and give warfarin – Warfarin initially
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